Liver Specific Function Enhancement by Microvascular System Integrated within a Lab-on-chip Device
نویسندگان
چکیده
We report a lab-on-chip device to study liver function enhancement by mimicking a liver tissue with its sinusoid on a 3D biomimetic chip. The device procures a thin polydimethylsiloxane membrane with an array of holes etched in it and sandwiched in the center of the microchannel to form upper and lower microchambers. Hepatocytes and fibroblasts were co-cultured on the upper chamber to mimic liver while the endothelial cells were cultured at the bottom micro chamber to provide nutrients to the in vitro reconstructed liver tissue in the upper chamber and as well to mimic vascular system at the cellular scale.
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